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This Concept Map, created with IHMC CmapTools, has information related to: Asthma edited, Arachidonic acid conversion to leukotrienes effects ↓ edema ↓ mucus secretion ↓ eosinophil counts ↓ smooth muscle constriction, inhaled corticosteroid affects dual pathways of inflammation, TYPE 1 HYPERSENSITIVITY PROCESS mediators Histamine, Early Phase (minutes) releases Cysteinyl Leukotrienes, anti- inflammatory slow anti-inflammatory drugs, pathophysiology leads to airway hyperactivity, Intermittent ɜ days OR ɜ consecutive wks Moderate-severe, cytokines released from activated mast & helper T cells results in constricted bronchiole, rhinitis, eczema, conjuctivitis, allergens cross link IgE's on mast cells results in obstructed airway, TYPE 1 HYPERSENSITIVITY PROCESS mediators IgE, Mild exhibits all of following - Normal Sleep - No impariment of daily activities, sport and leisure - No impairment of work & school - Sx present, but NOT troublesome, treatment bronchodialators, rhinitis Sx Runny nose, anti- inflammatory steroids, bronchodialators beta agonists, anti- inflammatory release inhibitors, treatment anti- inflammatory, beta agonists LABA, bronchodialators Theophylline, Moderate-severe exhibits ≥1 of the following -Sleep disturbance -Impairment of daily activities, sport, & leisure - imparment or work & school -Troublesome Sx